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Cytadsorption of Mycoplasma pulmonis to rat ependyma
Infection and Immunity
|October 1, 1981
Abstract:
Mycoplasma pulmonis was inoculated intracerebrally into neonatal rats. Hydrocephalus was induced, and the lateral ventricles and aqueduct were examined by scanning electron microscopy. Mycoplasmas were observed to be cytadsorbed to the ependymal surface.
Insights
Mycoplasma pulmonis infection in neonatal rats caused hydrocephalus. Scanning electron microscopy revealed the mycoplasmas attached to the ependymal surface lining the ventricles.
Area of Science:
- Neuroscience
- Microbiology
- Pathology
Background:
- Hydrocephalus is a condition characterized by the abnormal accumulation of cerebrospinal fluid in the brain.
- Mycoplasma infections can affect various organ systems, but their role in inducing hydrocephalus is not well-established.
Purpose of the Study:
- To investigate the pathological effects of Mycoplasma pulmonis inoculated intracerebrally in neonatal rats.
- To examine the interaction between Mycoplasma pulmonis and the ependymal lining of the brain ventricles.
Main Methods:
- Neonatal rats were intracerebrally inoculated with Mycoplasma pulmonis.
- Scanning electron microscopy was used to examine the lateral ventricles and aqueduct.
Main Results:
- Intracerebral inoculation of Mycoplasma pulmonis successfully induced hydrocephalus in neonatal rats.
- Scanning electron microscopy revealed Mycoplasma pulmonis adhering to the ependymal surface of the lateral ventricles and aqueduct.
Conclusions:
- Mycoplasma pulmonis can induce hydrocephalus in neonatal rats through adherence to the ependymal cells.
- This study highlights a potential mechanism for Mycoplasma-induced neurological complications.