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Vaginal progesterone for contraception

A Victor, T M Jackanicz, E D Johansson

    Fertility and Sterility
    |December 1, 1978
    PubMed
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    Silastic vaginal rings delivering progesterone and estradiol show potential for hormonal contraception. While not fully contraceptive, they influenced ovarian function and hormone levels in women.

    Area of Science:

    • Reproductive Endocrinology
    • Hormone Therapy
    • Contraception Research

    Background:

    • Vaginal rings offer a sustained-release drug delivery system.
    • Progesterone and estradiol are key hormones in the female reproductive system.

    Purpose of the Study:

    • To evaluate the impact of Silastic vaginal rings releasing progesterone (P) and estradiol (E) on ovarian function.
    • To assess the potential of these rings for hormonal contraception.

    Main Methods:

    • Nine women used Silastic vaginal rings releasing P (2.2 mg/day) or P and E (220 microgram/day) for 30 cycles.
    • Plasma levels of P and E were monitored.
    • Follicle-stimulating hormone (FSH) levels were assessed in a menopausal woman.

    Main Results:

    Keywords:
    Age FactorsBiologyClinical ResearchContraceptionContraceptive Agents, FemaleEndocrine SystemEstrogensFamily PlanningHormonesMenopauseMenstrual CycleMenstruationOvulation SuppressionPhysiologyProgestational HormonesProgesteroneReproductionResearch Methodology

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    • Ovulation occurred in 60% of treated cycles, leading to one pregnancy.
    • Mean plasma P levels were 0.9 ng/ml in anovulatory cycles.
    • Estradiol levels fluctuated within the normal range, with increased levels and decreased FSH in a menopausal subject.

    Conclusions:

    • Silastic vaginal rings releasing progesterone and estradiol are not suitable for contraceptive use at the tested dosages.
    • Higher dosages may offer a viable route for hormonal contraception via vaginal ring delivery.