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Related Experiment Videos

Withdrawal and pseudowithdrawal from diazepam therapy

A Winokur, K Rickels

    The Journal of Clinical Psychiatry
    |November 1, 1981
    PubMed
    Summary

    Patient attitudes and physician beliefs significantly impact diazepam treatment outcomes for anxiety. Understanding these factors is crucial for effective patient care and managing pseudowithdrawal reactions.

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    Area of Science:

    • Psychiatry
    • Pharmacology

    Background:

    • Diazepam is a commonly prescribed anxiolytic medication.
    • Patient and physician attitudes can influence treatment adherence and perceived efficacy.

    Observation:

    • Two cases from a double-blind placebo-controlled study of diazepam for anxiety are presented.
    • Case 1: A patient experienced withdrawal-like symptoms despite stable diazepam dosage and plasma levels, termed 'pseudowithdrawal'.
    • Case 2: A patient showed remarkable benefit from diazepam but faced physician reluctance due to negative publicity.

    Findings:

    • Patient perceptions and physician biases can mimic or mask actual drug effects.
    • Pseudowithdrawal reactions can occur even with therapeutic drug levels.
    • External factors like media coverage can override clinical judgment.

    Implications:

    • Emphasizes the need to consider psychological and social factors in pharmacotherapy.
    • Highlights the importance of physician education regarding diazepam's effects and withdrawal.
    • Suggests further controlled studies on long-term diazepam therapy and withdrawal management are warranted.

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