Pharmacokinetics of isosorbide dinitrate in rhesus monkey, cynomolgus monkey, and baboon

At 2 min after intravenous injection of isosorbide dinitrate (1 mg/kg), mean plasma drug concentrations were 565 +/- 66 (SD), 586 +/- 43, and 1572 +/- 253 ng/ml in the rhesus monkey, cynomolgus monkey, and baboon, respectively. Following a relatively short distribution phase, mean plasma concentrations declined with half-lives of 62, 23, and 24 min in these three species, respectively. The time course of plasma concentrations could be described by a two-compartment open model, although a one-compartment open model was adequate for obtaining some pharmacokinetic parameters. Statistically significant differences among the species were observed in areas under the plasma concentration-time curves, plasma half-lives, and volumes of distribution. The pharmacokinetics kinetics of isosorbide dinitrate in baboons most closely resembled those in humans.