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Regional lymph node metastasis from bladder cancer

J A Smith, W F Whitmore

    The Journal of Urology
    |November 1, 1981
    PubMed
    Summary
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    Bladder cancer patients with lymph node metastasis have a poor prognosis, with a 5-year survival rate of only 7%. Extrapelvic disease significantly impacts survival, suggesting pelvic lymphadenectomy may improve outcomes.

    Area of Science:

    • Oncology
    • Urology

    Background:

    • Bladder cancer with regional lymph node metastasis has a dismal prognosis.
    • Current treatments minimally alter outcomes for these patients.

    Purpose of the Study:

    • To analyze the survival rates and recurrence patterns of bladder cancer patients with positive regional lymph nodes.
    • To investigate the correlation between nodal involvement extent and recurrence interval.
    • To assess the potential impact of pelvic lymphadenectomy on patient survival.

    Main Methods:

    • Retrospective analysis of 134 bladder cancer patients undergoing radical cystectomy with positive regional lymph nodes.
    • Stratification of patients based on the extent of nodal disease.

    Main Results:

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  • The 5-year survival rate was only 7%.
  • 82% of patients died from bladder cancer.
  • A correlation was observed between the level of nodal involvement and the interval to recurrence.
  • 38% died of distant disease, while 25% had only pelvic recurrence.

    • Conclusions:

    • Extrapelvic disease is a major determinant of patient survival in bladder cancer with lymph node metastasis.
    • Systematic bilateral pelvic lymphadenectomy may offer a therapeutic benefit.