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Relationship between hypoxic and hypercapnic ventilatory responses in man

Y Kawakami, T Yoshikawa, A Shida

    The Japanese Journal of Physiology
    |January 1, 1981
    PubMed
    Summary
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    Ventilatory responses to hypoxia and hypercapnia are not strongly linked and are unaffected by aging in healthy individuals. Family history of lung disease significantly impacts hypoxic response but not hypercapnic response.

    Area of Science:

    • Physiology
    • Respiratory Medicine
    • Pulmonary Function Testing

    Background:

    • Understanding ventilatory control is crucial for respiratory health.
    • Factors like genetics, family history, age, and sex can influence respiratory responses.
    • Previous research has not fully elucidated the interrelationship between hypoxic and hypercapnic ventilatory responses or the impact of aging.

    Purpose of the Study:

    • To investigate the relationship between ventilatory responses to hypoxia and hypercapnia in healthy individuals.
    • To examine the influence of sex, age, family history, and genetics on these ventilatory responses.
    • To determine if aging alters ventilatory control mechanisms.

    Main Methods:

    • Measured ventilatory responses to hypoxia (A) and hypercapnia (S) in 127 healthy subjects using a dual system for independent control of PaO2 and PaCO2.

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  • Classified subjects by sex, age, family history (including twins), and genetic factors.
  • Measured mouth occlusion pressure (P0.1) during air breathing.

    • Main Results:

    • Hypoxic ventilatory response (A) was significantly lower in subjects with a family history of chronic lung diseases compared to those without (80 vs. 138 L/min/mmHg, P < 0.001).
    • Hypercapnic ventilatory response (S) did not significantly differ between groups.
    • Ventilatory responses (A and S) were not interrelated with each other, nor influenced by age, sex, familial factors, or genetics.
    • Mouth occlusion pressure (P0.1) did not correlate with either hypoxic or hypercapnic responses.

    Conclusions:

    • Hypoxic and hypercapnic ventilatory responses are largely independent of each other.
    • The aging process does not significantly alter ventilatory responses to hypoxia or hypercapnia in healthy individuals.
    • Family history of chronic lung diseases is a significant factor influencing hypoxic ventilatory response.