Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epinephrine and potassium homeostasis

R A DeFronzo, M Bia, G Birkhead

    Kidney International
    |July 1, 1981
    PubMed
    Summary

    Epinephrine improves potassium tolerance by enhancing non-kidney potassium excretion, an effect blocked by propranolol. This highlights epinephrine

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Insulin Secretion Predicts the Response to Antidiabetic Therapy in Patients With New-onset Diabetes.

    The Journal of clinical endocrinology and metabolism·2021
    Same author

    Impact of ethnicity and obesity on insulin resistance in two ethnic groups at very high risk of type 2 diabetes.

    Diabetes & metabolism·2016
    Same author

    Revitalization of pioglitazone: the optimum agent to be combined with a sodium-glucose co-transporter-2 inhibitor.

    Diabetes, obesity & metabolism·2016
    Same author

    The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo.

    Diabetic medicine : a journal of the British Diabetic Association·2014
    Same author

    Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): a randomized trial.

    Diabetes, obesity & metabolism·2014
    Same author

    Metabolites as novel biomarkers for childhood obesity-related traits in Mexican-American children.

    Pediatric obesity·2014

    Area of Science:

    • Cardiovascular Physiology
    • Renal Physiology
    • Endocrinology

    Background:

    • Potassium homeostasis is crucial for cellular function.
    • Epinephrine is known to influence electrolyte balance.
    • The specific mechanisms of epinephrine's effect on potassium metabolism require further elucidation.

    Purpose of the Study:

    • To investigate the impact of epinephrine on potassium tolerance and metabolism.
    • To determine the role of beta-adrenergic receptors in epinephrine's potassium-regulating effects.
    • To differentiate the contributions of extrarenal and renal pathways to potassium disposal.

    Main Methods:

    • Four infusion protocols in six subjects: potassium chloride alone, epinephrine plus potassium chloride, propranolol plus epinephrine plus potassium chloride, and propranolol plus potassium chloride.
    • Intravenous infusions of potassium chloride, epinephrine, and propranolol at specified doses.
    • Measurement of plasma potassium levels and urinary potassium excretion (UkV).

    Main Results:

    • Epinephrine significantly improved potassium tolerance, increasing extrarenal potassium disposal twofold.
    • Epinephrine markedly inhibited urinary potassium excretion (UkV), reducing it below basal rates.
    • Propranolol, a beta-blocker, completely reversed epinephrine's effects on both extrarenal and renal potassium handling.
    • Propranolol alone decreased extrarenal potassium disposal and increased UkV.

    Conclusions:

    • Epinephrine enhances extrarenal potassium disposal and inhibits renal excretion, thereby ameliorating hyperkalemia.
    • These effects are mediated via beta-adrenergic receptor stimulation.
    • Insulin plays a minimal role in epinephrine's potassium-regulating actions.

    Related Experiment Videos