Is hypergastrinaemia associated with rheumatoid arthritis?
Gut
|November 1, 1978
Summary
Raised serum gastrin levels in rheumatoid arthritis (RA) patients are less common than previously thought. When hypergastrinaemia is present in RA, it is associated with achlorhydria and atrophic gastritis.
Area of Science:
- Gastroenterology
- Rheumatology
- Endocrinology
Background:
- Previous reports suggested a high incidence of elevated serum gastrin in rheumatoid arthritis (RA) patients.
- Gastrin plays a role in gastric acid secretion and mucosal health.
Purpose of the Study:
- To investigate the incidence of raised serum gastrin levels in patients with rheumatoid arthritis (RA).
- To characterize gastrin responses to a meal in RA patients with and without hypergastrinaemia.
- To explore the association between hypergastrinaemia and gastric pathology in RA.
Main Methods:
- Serum gastrin concentrations were measured in 54 RA patients.
- Gastrin responses (G17 and total carboxyl-terminal) to a protein meal were assessed using radioimmunoassay.
- Acid output studies and gastric mucosal biopsies were performed in hypergastrinaemic patients.
Main Results:
- Only 6% of RA patients exhibited basal hypergastrinaemia.
- Hypertgastrinaemic RA patients showed significantly greater and more prolonged gastrin responses to a meal (P < 0.02).
- Two hypergastrinaemic patients were achlorhydric and had atrophic gastritis.
Conclusions:
- Basal hypergastrinaemia is uncommon in RA patients and is associated with achlorhydria.
- The incidence of achlorhydria in RA is comparable to the general population.
- Atrophic gastritis may be linked to hypergastrinaemia in a subset of RA patients.
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