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Computed tomography in mitochondrial cytopathy

J Egger, B E Kendall

    Neuroradiology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Computed tomography (CT) revealed focal low density lesions and atrophy in patients with mitochondrial cytopathies. These abnormalities often progressed over time, aiding in diagnosis.

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    Area of Science:

    • Neurology
    • Radiology
    • Genetics

    Background:

    • Mitochondrial cytopathies are a group of inherited disorders affecting cellular energy production.
    • Clinical manifestations are diverse, often involving muscle and the central nervous system.
    • Computed tomography (CT) plays a role in characterizing neurological involvement.

    Purpose of the Study:

    • To investigate and describe the computed tomographic (CT) findings in patients with proven mitochondrial cytopathies.
    • To correlate CT findings with clinical diagnoses, including mitochondrial myopathy, Kearns-Sayre syndrome, and ophthalmoplegia plus.
    • To document the progression of CT abnormalities over time.

    Main Methods:

    • Retrospective analysis of clinical data and CT scans from 11 patients with confirmed mitochondrial cytopathies.

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  • Detailed review of CT images to identify and characterize lesions, atrophy, and calcifications.
  • Comparison of CT findings with established literature.

    • Main Results:

    • CT scans demonstrated focal low-density lesions in the basal ganglia and white matter in all cases.
    • Cerebral atrophy, ranging from mild to severe and diffuse, was observed.
    • Calcification in the basal ganglia, previously reported, was not present in this series.
    • Serial CT examinations showed a progressive increase in the observed abnormalities.

    Conclusions:

    • CT imaging reveals characteristic patterns of brain abnormalities in mitochondrial cytopathies, including lesions and atrophy.
    • The observed progression of CT findings over time is a significant feature.
    • CT findings contribute to the differential diagnosis of mitochondrial cytopathies and related neurological disorders.