Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exfoliation glaucoma: a quantitative perfusion and ultrastructural study

T M Richardson, D L Epstein

    Ophthalmology
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of Y27632 on keratinocyte procurement and wound healing.

    Clinical and experimental dermatology·2013
    Same author

    Early treatment study of elevated intraocular pressure (2).

    Journal of glaucoma·2009
    Same author

    Will there be a remedy to reverse the changes in the trabecular meshwork and the optic nerve? A personal point of view on glaucoma therapy.

    Journal of glaucoma·2009
    Same author

    Coiled-coil targeting of myocilin to intracellular membranes.

    Experimental eye research·2006
    Same author

    Higher densities of distributed pheromone sources provide disruption of codling moth (Lepidoptera: Tortricidae) superior to that of lower densities of clumped sources.

    Journal of economic entomology·2006
    Same author

    Percutaneous management of perianastomotic stenosis in arteriovenous fistulae: results of a prospective study.

    Kidney international·2006
    Same journal

    Metastasis of Nasopharyngeal Squamous Cell Carcinoma to the Angle.

    Ophthalmology·2026
    Same journal

    Endocrine Mucin-Producing Sweat Gland Carcinoma of Eyelid.

    Ophthalmology·2026
    Same journal

    Multimodal Imaging of Optic Nerve Invasion in Unilateral Retinoblastoma.

    Ophthalmology·2026
    Same journal

    Avacincaptad Pegol Slows Progressive Ellipsoid Zone Degradation/Loss in Eyes With Geographic Atrophy.

    Ophthalmology·2026
    Same journal

    Access to Intravitreal Anti-VEGF Drugs in Persons with Medicare Advantage Compared with Medicare Fee-For-Service.

    Ophthalmology·2026
    Same journal

    Re: Dones et al.: Emergency department use of ocular point-of-care ultrasound and its utility in diagnosis at a tertiary academic medical center (Ophthalmology. 2026;133:720-727).

    Ophthalmology·2026
    See all related articles

    Exfoliation syndrome causes glaucoma by damaging Schlemm's canal and the juxtacanalicular region, impeding aqueous humor outflow. Trabecular meshwork cells did not uptake exfoliation material, contrary to expectations.

    Area of Science:

    • Ophthalmology
    • Pathology

    Background:

    • Exfoliation syndrome is a common genetic disorder associated with secondary glaucoma.
    • Understanding the pathophysiology of aqueous humor outflow in exfoliation syndrome is crucial for glaucoma management.

    Observation:

    • Postmortem analysis of eyes from a patient with exfoliation syndrome was performed using quantitative perfusion and electron microscopy.
    • The study correlated clinical findings with detailed postmortem examination of the aqueous outflow system.

    Findings:

    • The corneoscleral trabecular meshwork spaces were open and largely free of exfoliation material.
    • Trabecular cells appeared normal and did not uptake exfoliation material, differing from their known capacity for pigment uptake.
    • Significant pathology was observed in Schlemm's canal, including destruction and accumulation of exfoliation material in the juxtacanalicular region, which likely increased aqueous outflow resistance.

    Related Experiment Videos

    Implications:

    • The findings suggest that damage to Schlemm's canal and the juxtacanalicular region are key factors in the elevated intraocular pressure seen in exfoliation syndrome.
    • This detailed correlation of clinical and postmortem data provides valuable insights into the mechanisms of glaucoma in exfoliation syndrome.