[Effect of the pesticide fundazol on induced sclerotic processes]

The effect of fundazol pesticide (methyl-l-butylcarbamoilbenzimidazol carbamate) on the development of sclerotic processes in aorta of experimental animals was followed up, induced by atherogenic diet (cholesterol, cholic acid and vitamin D2). The experiment was carried out on 144 albino rats, both sexes, administered 250 mG/kg and 1000 mg/kg fundazol orally in the course of 30 days, singly or in combination with atherogenic diet, The course of the metabolic processes was studied as well as the structural characteristic of the fibrous structures and the basic intercellular substance in the vascular wall of aorta by biochemical (enzymatic activity of some dehydrogenases and phosphatases, the quantity of soluble and insoluble collagen and elastin proteins, the content of glycosamioglycans - sulphated and unsulphated) and routine morphological and histochemical methods. The combined administration of both factors leads to potentiation of the effect of atherogenic diet by fundazol, even with a lower dose, the developing pathologic process being more severe and progressing more rapidly as compared with the single effect of the atherogenic factor.