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Related Experiment Videos

When is a positive nasal challenge test clinically relevant?

M Reinert

    Respiration; International Review of Thoracic Diseases
    |January 1, 1981
    PubMed
    Summary

    This study investigated allergen threshold concentrations in nasal allergy tests. For pollens and animal fur, specific thresholds were identified, but mites lacked a clear threshold, limiting nasal test informativeness.

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    Area of Science:

    • Allergen immunotherapy
    • Clinical immunology
    • Rhinology

    Background:

    • Allergic rhinitis affects a significant portion of the population.
    • Intranasal allergen challenge is a diagnostic tool for allergic rhinitis.
    • Understanding allergen thresholds is crucial for accurate diagnosis and treatment.

    Purpose of the Study:

    • To determine threshold concentrations for various allergens using intranasal challenge.
    • To compare the efficacy of nasal testing for allergens with and without established thresholds.
    • To evaluate the diagnostic value of nasal tests in patients with manifest and latent allergies.

    Main Methods:

    • Intranasal allergen challenge was performed on 339 subjects with manifest or latent allergies.
    • Allergens tested included grass pollens, tree pollens, cat fur, dog hair, mites, and horse hair.
    • Concentrations of allergens were varied to identify reaction thresholds.

    Main Results:

    • Threshold concentrations were identified for pollens and animal fur, varying between latent and manifest allergies.
    • For pollens, thresholds ranged from 0.01% to 1% w/v.
    • No threshold concentration was found for mites, suggesting limitations for nasal testing in such cases.

    Conclusions:

    • Specific threshold concentrations exist for certain allergens like pollens and animal fur.
    • Intranasal allergen testing is informative when thresholds are established.
    • For allergens like mites, where no threshold is found, nasal tests may offer limited diagnostic value compared to skin tests.

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