Unusual manifestations of hypereosinophilia

The hypereosinophilic syndrome is a heterogeneous group of clinical disorders comprising a spectrum of pathologic conditions. We have described a patient with chronic eosinophilia for eight years. His course of progressive organ dysfunction and tissue infiltration by eosinophils, with myelofibrosis, lytic bone lesions, hepatomegaly, and generalized adenopathy are most compatible with a chronic myeloproliferative syndrome.