Sella turcica erosion and transient hypogonadism in the multiple endocrine deficiency syndrome

A 42-year-old man presented with clinical and biochemical evidence of hypothyroidism, hypoadrenalism, and hypogonadism. Initial diagnostic studies suggested intrinsic pituitary disease and were supported by the finding of a roentgenographically abnormal sella turcica. Detailed endocrine evaluation subsequently showed normal pituitary function and primary target organ deficiencies. Adrenal and thyroid hormone replacement resulted in complete resolution of clinical symptoms and abnormalities of gonadal function. Thorough endocrine evaluation is needed in patients with multiple endocrine deficiencies.