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Related Experiment Videos

Food allergy - a definition

C M Macfarlane, E G Shephard, J R Joubert

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |December 5, 1981
    PubMed
    Summary
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    This study on radio-allergosorbent tests (RAST) suggests reserving "food allergy" for patients with a polyclonal IgE response to food. This finding aids in precise allergy diagnosis and understanding immune responses.

    Area of Science:

    • Immunology
    • Allergy Diagnostics

    Background:

    • Radio-allergosorbent test (RAST) is a common method for detecting specific IgE antibodies.
    • Distinguishing between specific food allergies and broader allergic responses is clinically important.

    Purpose of the Study:

    • To analyze RAST results in patients with positive food allergen tests.
    • To propose a refined definition for 'food allergy' based on IgE response patterns.

    Main Methods:

    • RAST results were plotted as percentage binding to allergen discs versus serum IgE levels.
    • Patients with positive food allergen tests were categorized based on their response to food-only versus food and other allergens.
    • Comparison was made with RAST patterns in patients infected with Ascaris lumbricoides.

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    Main Results:

    • A division of patients was observed based on their allergen response profiles.
    • This pattern mirrored findings in Ascaris lumbricoides-infested patients undergoing RAST.
    • Polyclonal IgE responses were identified in a subset of patients.

    Conclusions:

    • The term 'food allergy' should be specifically applied to patients exhibiting a polyclonal IgE response to ingested foods.
    • This classification aids in differentiating true food allergies from other allergic conditions.
    • Understanding IgE response patterns is crucial for accurate allergy diagnosis.