Related Experiment Videos
[Resistance to griseofulvin (author's transl)]
Zeitschrift Fur Hautkrankheiten
|October 15, 1981
Summary
Griseofulvin resistance in dermatophytes remains rare, with only a few cases observed over decades. The study found no increase in resistant strains, suggesting other factors cause treatment non-response.
Area of Science:
- Medical Mycology
- Antimicrobial Resistance
Context:
- Griseofulvin is a long-standing antibiotic for fungal skin infections.
- Early use showed few griseofulvin-resistant dermatophytes.
- No significant increase in resistant strains observed during the 1970s.
Purpose:
- To assess the incidence of griseofulvin-resistant dermatophytes over time.
- To investigate the prevalence of primary versus secondary griseofulvin resistance.
Summary:
- Studied 489 dermatophyte strains; only 5 (4 Trichophyton rubrum, 1 Trichophyton mentagrophytes) showed resistance at 100 gamma/ml.
- Identified resistance as secondary, not primary.
- Concluded that resistant dermatophytes do not explain most treatment failures.
Impact:
- Current data suggests no emerging problem of widespread griseofulvin resistance.
- Highlights the need to consider other reasons for non-response to griseofulvin therapy.
- Informs clinical practice regarding antifungal treatment efficacy.