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[Kidney involvement in "mixed connective tissue disease" (Sharp syndrome)]
Zeitschrift Fur Urologie Und Nephrologie
|July 1, 1981
Summary
Sharp syndrome, a mixed connective tissue disease, frequently involves the kidneys. Renal biopsy is crucial for diagnosis and treatment, even with normal urine tests, aiding therapeutic and prognostic decisions.
Area of Science:
- Rheumatology
- Nephrology
- Immunology
Background:
- Sharp syndrome is a mixed connective tissue disease characterized by overlapping symptoms of scleroderma, visceral erythematosus, dermatomyositis, and rheumatoid arthritis.
- Diagnosis relies on clinical presentation and immunological profiling.
Observation:
- This study presents three cases of Sharp syndrome with significant kidney involvement.
- Kidney pathology was evaluated using histological and immunohistological methods.
Findings:
- Renal involvement is a common feature of Sharp syndrome, evident even without urinary abnormalities.
- Histological and immunohistological analysis of kidney biopsies reveals crucial details about the disease's impact.
Implications:
- Renal biopsy is recommended for patients with Sharp syndrome, irrespective of urine test results.
- Biopsy findings are essential for guiding therapeutic strategies and determining patient prognosis.