[Amino acid substitution with Infesol in chronically hemodialyzed children]

The L-amino acid solution Infesol and the DL-amino solution Alvesin-new were one after the other investigated for their ability as a substitution of losses of amino acids conditioned by dialysis in 4 children with chronic renal insufficiency. The permanent intravenous drip infusion of 200 ml Infesol during 2 hours after the end of the haemodialysis led to a slight increase of the serum amino acids, which had normalized in a control 12 hours after the beginning of the infusion. The mean value of urea in the serum had increased after 2 hours by 17.60, after 12 hours by 3.65 mg compared with the initial value after the dialysis. The analogous infusion of Alvesin-new led to an on an average higher increase of the serum amino acids in the same patients. In the control after 12 hours the methionine-isoleucine, phenylalanine and arginine values in the serum were still significantly increased compared with the Infesol series. At the same time the mean value of serum urea increased by 80.95 mg/100 ml after two hours. After 12 hours it had increased by 105.5 mg/100 ml compared with the initial value. Thus, the solution of L-amino acid infesol is suitable for the compensation of losses of amino acids conditioned by dialysis. However, its application is reserved for larger dietetically not compensable condition of the lack of amino acids and protein.