Metrizamide and metrizoate for cardioangiography in infants and children

Metrizamide was compared with metrizoate in a double blind investigation. Cardioangiography was performed in 30 infants and children below 2 years of age with congenital heart disease. Adverse reactions were few and unimportant. Changes in ECG, ventricular pressure and heart rate during and after the contrast injections were recorded. The side effects were slight in both groups. Metrizamide caused less changes than metrizoate at a statistically significant level.