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Pathologic investigation of cutaneous stretch

H L Wechsler, E R Fisher

    International Journal of Dermatology
    |November 1, 1978
    PubMed
    Summary

    Skin stretching causes wounding and repair. Evenly stretched skin shows thickened collagen, suggesting increased synthesis or decreased degradation, possibly due to molecular-level defects.

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    Area of Science:

    • Dermatology
    • Biochemistry
    • Tissue Engineering

    Background:

    • Skin stretching is a common biomechanical stress.
    • Understanding collagen's response to mechanical forces is crucial for tissue repair and regeneration.

    Purpose of the Study:

    • To investigate the effects of uneven and even skin stretching on rat skin.
    • To determine the impact of mechanical stretch on dermal collagen synthesis and degradation.

    Main Methods:

    • Microscopic and light microscopic examination of rat skin.
    • Analysis of dermal collagen structure and thickness under varying stretch conditions.

    Main Results:

    • Uneven stretching induced microscopic wounding and subsequent repair.
    • Even stretching led to markedly thickened and homogeneous dermal collagen compared to controls.
    • Increased skin thickness occurred despite increased surface area.

    Conclusions:

    • Mechanical stretch, even when uniform, may induce a 'wounded' state at a molecular level.
    • Stretch may enhance dermal collagen synthesis or reduce its degradation.
    • Further investigation into molecular or biochemical defects is warranted to explain collagen turnover.

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