Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sudden death associated with thyroid hormone abuse

S Bhasin, W Wallace, J B Lawrence

    The American Journal of Medicine
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Corrigendum to "Plasma growth differentiation factors 8 and 11 levels in cats with congestive heart failure secondary to hypertrophic cardiomyopathy" [J Vet Cardiol 25 (2019 Oct) 41-51].

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024
    Same author

    Evidence of a J/ψK_{S}^{0} Structure in B^{0}→J/ψϕK_{S}^{0} Decays.

    Physical review letters·2023
    Same author

    Measurement of the Ratios of Branching Fractions R(D^{*}) and R(D^{0}).

    Physical review letters·2023
    Same author

    Measurement of the Prompt D^{0} Nuclear Modification Factor in p-Pb Collisions at sqrt[s_{NN}]=8.16  TeV.

    Physical review letters·2023
    Same author

    Measurement of the Branching Fractions B(B^{0}→pp[over ¯]pp[over ¯]) and B(B_{s}^{0}→pp[over ¯]pp[over ¯]).

    Physical review letters·2023
    Same author

    Measurement of the Time-Integrated CP Asymmetry in D^{0}→K^{-}K^{+} Decays.

    Physical review letters·2023

    Factitious hyperthyroidism from excessive L-thyroxine intake can cause sudden death, potentially from drug-induced myocarditis. This risk exists even without coronary artery disease, highlighting the dangers of L-thyroxine abuse.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Toxicology

    Background:

    • Deliberate L-thyroxine overdose can lead to severe hyperthyroidism.
    • Hyperthyroidism may present atypically, delaying diagnosis.
    • Sudden cardiac death is a potential complication.

    Observation:

    • Three cases of sudden death in patients with factitious hyperthyroidism due to L-thyroxine abuse are presented.
    • Two patients had atypical presentations, with hyperthyroidism unrecognized on admission.
    • Autopsy findings in two patients revealed myocarditis and, in one, myocardial infarction with coronary thrombosis.

    Findings:

    • Factitious hyperthyroidism can cause instantaneous death, presumed to be from ventricular fibrillation.
    • Sudden death may occur in the absence of coronary artery disease.

    Related Experiment Videos

  • Drug-induced myocarditis is a potential mechanism linking L-thyroxine abuse to sudden cardiac events.

    • Implications:

    • Physicians should consider factitious hyperthyroidism in unexplained sudden cardiac death.
    • Early recognition of atypical hyperthyroidism presentations is crucial.
    • L-thyroxine abuse poses significant cardiovascular risks beyond typical hyperthyroid symptoms.