Papillary adenocarcinoma of the prostatic urethra with clear-cell appearance

The second reported papillary prostatic urethral carcinoma displaying an unusual clear-cell or so-called mesonephroid histologic appearance is described. Neoplasms arising from the utricular region have generated considerable discussion of their histogenesis and hormone-responsiveness. A review of the literature as well as consideration of this case suggests that the lesion's clear-cell appearance should not be used as evidence for müllerian derivation from the utricle. The authors favor a periurethral gland origin for this particular tumor.