Several heat-sensitive properties of the MULv-induced YAC lymphoma

A therapeutic heat dose of 44.0 +/- 0.1 degrees C/20 min caused either temporary or permanent inhibition of tumor growth in 86% (25/29) of the CAF1/J female mice inoculated in the footpad with MULv-induced YAC lymphoma and heated when the tumor was well established. Heating before the tumor is well established is less effective because the heat-sensitivity of the tumor increases as it grows in the host. The transplantability of this tumor is more effectively impaired when heated tumor tissue is left in situ for 24 h post-heating than if it is excised immediately after heating and implanted in host mice.