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Plasma clonidine concentration and pharmacologic effect

M J Hogan, J D Wallin, L C Chu

    Clinical Pharmacology and Therapeutics
    |December 1, 1981
    PubMed
    Summary
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    Clonidine plasma levels peak within 2 hours and stabilize, correlating with blood pressure reduction in hypertensive patients. This suggests monitoring clonidine levels can optimize hypertension treatment and support 12-hour dosing intervals.

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Clinical Pharmacy

    Background:

    • Hypertension is a prevalent condition requiring effective pharmacotherapy.
    • Clonidine is an oral antihypertensive agent with variable patient responses.
    • Understanding clonidine pharmacokinetics is crucial for optimizing therapeutic outcomes.

    Purpose of the Study:

    • To analyze clonidine plasma concentrations over time in hypertensive patients.
    • To correlate plasma clonidine levels with blood pressure reduction and side effects.
    • To evaluate the suitability of 12-hour dosing intervals for clonidine therapy.

    Main Methods:

    • Sequential plasma sampling was performed in 14 hypertensive subjects.
    • Subjects received standard oral doses of clonidine (0.1-0.6 mg twice daily).

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  • Plasma clonidine concentrations, diastolic blood pressure, and side effects were monitored.

    • Main Results:

    • Clonidine plasma concentration increased for 2 hours, then stabilized over 12 hours.
    • The percentage fall in diastolic blood pressure correlated significantly with plasma clonidine levels.
    • No significant correlation was found between plasma clonidine levels and reported side effects.

    Conclusions:

    • Plasma clonidine determination may aid in optimizing hypertension treatment.
    • Clonidine appears effective and suitable for administration at 12-hour intervals.
    • Therapeutic drug monitoring of clonidine could improve patient management in hypertension.