Jove
Visualize
Contact Us

Related Experiment Videos

Morphinelike arousal by methadone during sleep

W B Pickworth, G L Neidert, D C Kay

    Clinical Pharmacology and Therapeutics
    |December 1, 1981
    PubMed
    Summary

    Methadone and morphine have similar acute effects on sleep, increasing wakefulness and decreasing sleep quality. However, long-term use shows differences in their impact on arousal.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Levels of mint and wintergreen flavorants: smokeless tobacco products vs. confectionery products.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2009
    Same author

    Pupillometry in the detection of concomitant drug use in opioid-maintained patients.

    Methods and findings in experimental and clinical pharmacology·2004
    Same author

    Nicotine delivery capabilities of smokeless tobacco products and implications for control of tobacco dependence in South Africa.

    Tobacco control·2004
    Same author

    Cyclazocine: comparison to hydromorphone and interaction with cocaine.

    Behavioural pharmacology·2004
    Same author

    Comparison of the nicotine content of tobacco used in bidis and conventional cigarettes.

    Tobacco control·2001
    Same author

    Pharmacodynamic effects of new de-nicotinized cigarettes.

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2000
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Pharmacology
    • Sleep Medicine
    • Neuroscience

    Background:

    • Opioid medications like methadone and morphine are widely used for pain management.
    • Understanding their acute and chronic effects on sleep is crucial for patient care.
    • Previous research suggests differing long-term effects on arousal between methadone and morphine.

    Purpose of the Study:

    • To compare the acute effects of methadone and morphine on sleep patterns.
    • To investigate if methadone induces insomnia similar to morphine.
    • To examine differences in arousal effects between the two opioids.

    Main Methods:

    • A randomized, double-blind, crossover study design was employed.
    • Seven non-dependent male opiate addicts participated.
    • Sleep patterns were monitored after administration of methadone, morphine, or placebo via intramuscular injection.

    Main Results:

    • Methadone and morphine demonstrated equipotent effects on increasing wakefulness and drowsiness.
    • Both drugs significantly reduced sleep efficiency and delta sleep.
    • Latency to rapid eye movement sleep (REMS) increased, while total REMS decreased with both opioids.

    Conclusions:

    • Acute administration of methadone produces sleep-arousal effects comparable to morphine.
    • This contrasts with observed differences in long-term administration, where morphine causes persistent arousal and methadone does not.
    • Findings highlight distinct chronic effects despite similar acute sleep disruption profiles.

    Related Experiment Videos