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A stable parenteral solution of apomorphine

W J Decker, D G Corby, H F Combs

Clinical Toxicology

|July 1, 1981

Summary

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A new sterile apomorphine preparation was developed for parenteral use. This stable formulation maintains potency and clarity for over a year when stored properly.

Area of Science:

Pharmaceutical Chemistry
Drug Formulation
Parenteral Drug Delivery

Background:

Apomorphine is a dopamine agonist used for Parkinson's disease.
Parenteral formulations require stability and sterility.
Oxidation can degrade apomorphine, limiting its shelf-life.

Purpose of the Study:

To develop a sterile and stable parenteral apomorphine formulation.
To ensure the long-term potency and physical characteristics of the apomorphine solution.

Main Methods:

Dissolving apomorphine hydrochloride in reduced l-ascorbic acid.
Sterilization via 0.22-micrometer Millipore filtration.
Packaging under nitrogen and storage at 5°C in the dark.

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Main Results:

The prepared apomorphine solutions were water-clear.
The formulation demonstrated stability and retained potency for at least 1 year.
The formulation was suitable for parenteral administration.

Conclusions:

A stable, sterile parenteral apomorphine preparation can be achieved.
Reduced l-ascorbic acid acts as an effective stabilizer.
The developed formulation offers a reliable option for apomorphine administration.