Toxic effects of quinacrine hydrochloride in rhesus monkeys

The toxic effects of intraperitoneal, intrauterine and intravenous administration of quinacrine hydrochloride solution were evaluated in female adult rhesus monkeys (Macaca mulatta). A single intraperitoneal injection of 400 mg and above resulted in the development of toxic manifestations leading to death of monkeys. Intrauterine instillation of 500 mg of quinacrine was well tolerated and did not produce any toxic effects. However, intravenous injection of 100 and 75 mg was lethal to the animals.