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Tracheobronchopathia osteochondroplastica. A clinical bronchoscopic and spirometric study

R Lundgren, N L Stjernberg

    Chest
    |December 1, 1981
    PubMed
    Summary

    Tracheobronchopathia osteochondroplastica (TO) is a rare condition causing airway growths. This study found TO in 9 of 2,180 bronchoscopies, often presenting with chronic respiratory symptoms and obstructive lung function.

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    Area of Science:

    • Pulmonology
    • Rare Diseases
    • Respiratory Medicine

    Background:

    • Tracheobronchopathia osteochondroplastica (TO) is an uncommon condition characterized by the formation of osteocartilaginous nodules in the airway walls.
    • While considered rare, TO may be underdiagnosed, potentially occurring more frequently than previously recognized.
    • Symptoms can be chronic and nonspecific, leading to delayed diagnosis.

    Purpose of the Study:

    • To investigate the prevalence and clinical characteristics of Tracheobronchopathia osteochondroplastica (TO) in patients undergoing bronchoscopy.
    • To describe the endoscopic and histopathological findings associated with TO.
    • To evaluate the pulmonary function in patients diagnosed with TO.

    Main Methods:

    • A retrospective review of 2,180 bronchoscopies performed over an eight-year period.

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  • Identification of patients with confirmed Tracheobronchopathia osteochondroplastica (TO) based on endoscopic and biopsy findings.
  • Analysis of patient demographics, clinical symptoms, bronchoscopic observations, histopathological results, and spirometry data.

    • Main Results:

    • Nine cases of Tracheobronchopathia osteochondroplastica (TO) were identified, representing an estimated prevalence in this cohort.
    • Patients were predominantly male (5/9) with a mean age of 60 years.
    • Common symptoms included chronic cough, expectoration, dyspnea, hemoptysis, and recurrent airway infections, with a mean duration of over ten years.
    • Bronchoscopy revealed characteristic papilla-like formations from the trachea to segmental bronchi.
    • Histopathology confirmed osteocartilaginous tissue in all biopsy specimens.
    • Spirometry demonstrated an obstructive pattern in eight out of nine patients.

    Conclusions:

    • Tracheobronchopathia osteochondroplastica (TO) is a significant cause of chronic airway disease that may be more prevalent than typically reported.
    • The characteristic endoscopic and histopathological findings are crucial for diagnosis.
    • Airway obstruction is a common finding in patients with TO, highlighting the need for respiratory function assessment.