Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucociliary transport and ultrastructural abnormalities in Polynesian bronchiectasis

D A Waite, S J Wakefield, J B Mackay

    Chest
    |December 1, 1981
    PubMed
    Summary

    Bronchiectasis patients often lack dynein arms in cilia, leading to impaired mucociliary clearance. This study found widespread ciliary abnormalities in Polynesian patients with this condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fibroblasts and eosinophils in normal fibroplasia of ferret vulval skin, shown by light and electron microscopy; with special reference to eosinophil degranulation.

    Connective tissue research·2000
    Same author

    Histological and ultrastructural features of atherosclerosis in progeria.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2000
    Same author

    Fine-needle aspiration cytology of a minimal carcinoma of the breast with neuroendocrine features.

    Diagnostic cytopathology·1998
    Same author

    Fine-needle aspiration cytology of malignant retroperitoneal paraganglioma.

    Diagnostic cytopathology·1998
    Same author

    Fine-needle aspiration cytology of renal angiomyolipoma: report of a case with immunocytochemical and electron microscopic findings.

    Diagnostic cytopathology·1998
    Same author

    Needle aspiration cytology, immunocytochemistry, and electron microscopic study in a case of carcinoid of the male breast.

    Diagnostic cytopathology·1993

    Area of Science:

    • Respiratory Medicine
    • Cell Biology
    • Genetics

    Background:

    • Bronchiectasis is a chronic lung condition characterized by permanent enlargement of the airways.
    • Ciliary dysfunction is implicated in various respiratory diseases, affecting mucus clearance.
    • Previous research suggests a link between ciliary abnormalities and bronchiectasis, but specific mechanisms require further investigation.

    Purpose of the Study:

    • To investigate ciliary structure and function in Polynesian patients with bronchiectasis.
    • To identify specific ciliary abnormalities, such as dynein arm defects, in affected individuals.
    • To assess the impact of these abnormalities on mucociliary clearance.

    Main Methods:

    • Electron microscopy was used to examine ciliated bronchial and nasal epithelium from 20 Polynesian bronchiectatic patients.

    Related Experiment Videos

  • Ciliary ultrastructure, focusing on dynein arms and other abnormalities, was analyzed.
  • Mucociliary clearance was quantitatively measured using gamma camera imaging of 99mTc sulfide dust.

    • Main Results:

    • All examined patients exhibited partial or complete loss of dynein arms in their cilia.
    • A high proportion (over 25%) of cilia displayed additional abnormalities.
    • Mucociliary clearance was markedly reduced or absent in the majority of patients.
    • Control groups showed infrequent ciliary abnormalities, highlighting the significance of findings in bronchiectasis patients.

    Conclusions:

    • Loss of dynein arms and other ciliary defects are prevalent in Polynesian bronchiectasis patients.
    • These ultrastructural abnormalities correlate with severely impaired mucociliary clearance.
    • The findings underscore the critical role of ciliary function in maintaining airway health and suggest potential genetic or environmental factors in this population.