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Related Experiment Videos

Neonatal screening for hypothyroidism in Greece

C Mengreli, K Kassiou, S Tsagaraki

    European Journal of Pediatrics
    |October 1, 1981
    PubMed
    Summary

    Greece screened 75,879 newborns for congenital hypothyroidism using thyroid stimulating hormone (TSH) tests. This newborn screening detected 18 cases, revealing an incidence of 1:4200, and initiated early treatment.

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    Area of Science:

    • Endocrinology
    • Neonatal screening
    • Public health

    Background:

    • Congenital hypothyroidism (CH) is a common preventable cause of intellectual disability.
    • Early detection and treatment are crucial to prevent developmental deficits.

    Purpose of the Study:

    • To report the initial year's experience with a statewide newborn screening program for CH in Greece.
    • To determine the incidence of CH in the screened population.

    Main Methods:

    • Radioimmunoassay for thyroid stimulating hormone (TSH) on dried blood spots.
    • Screening of 75,879 newborns within the first 5 days of life.

    Main Results:

    • Eighteen cases of primary CH were identified with serum TSH levels > 100 microIU/ml.
    • The incidence of CH was determined to be 1:4200.
    • One case was clinically diagnosed prior to screening.

    Conclusions:

    • The implemented screening program effectively identified cases of CH.
    • Early initiation of replacement therapy, between 22 and 50 days of life, was achieved.

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