[Effect of furosemide on intact and ischemic rat kidney cortical structures]

Biomicroscopy and microphotography of cortical structures of rat kidneys have shown that furosemide produces a significant increase in the internal and external diameters of the tubules without substantial change in the wall thickness and width of intertubular space. In renal ischemia, the wall thickness and external diameter of the tubules progressively increase. The majority of the tubules show the disappearance of the lumen. In the course of the blood flow recovery, the wall thickening remains unchanged. Ligation of the renal vessels in the presence of furosemide administration also leads to the collapse of the tubules. However, the thickness of the tubular wall decreases while the lumen rises during ischemia. The role of the hydrodynamic effect in the mechanism of anti-ischemic action of furosemid is discussed.