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Temperature effects on neuronal elements

R W Joyner

    Federation Proceedings
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    The Hodgkin-Huxley model accurately predicts how temperature affects action potential initiation and propagation. This model

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    Area of Science:

    • Neuroscience
    • Computational Biology
    • Biophysics

    Background:

    • Action potentials are fundamental to neuronal communication.
    • Temperature significantly influences neuronal excitability and signal propagation.
    • The Hodgkin-Huxley model is a cornerstone for understanding action potentials.

    Purpose of the Study:

    • To review experimentally determined temperature dependence of action potential parameters.
    • To compare experimental Q10 values with predictions from Hodgkin-Huxley equations.
    • To assess the accuracy of the Hodgkin-Huxley model in predicting temperature-dependent phenomena.

    Main Methods:

    • Literature review of experimentally determined Q10 values for action potential parameters.
    • Comparison of experimental data with theoretical Q10 values derived from Hodgkin-Huxley equations.

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  • Analysis of Hodgkin-Huxley model's predictive power for propagational failure.

    • Main Results:

    • Experimentally determined Q10 values largely align with Hodgkin-Huxley predictions.
    • The Hodgkin-Huxley model, using a Q10 of 3 for rate constants, accurately predicts most measured parameters.
    • The model effectively predicts temperature-dependent failure of action potential propagation at branch points.

    Conclusions:

    • The Hodgkin-Huxley model provides a robust framework for understanding temperature effects on action potentials.
    • The model's accuracy extends to complex scenarios like propagation failure influenced by geometry.
    • This validates the Hodgkin-Huxley model's applicability in diverse physiological conditions.