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Thyrotropin in human breast milk

A Tenore, L V Oberkotter, O Koldovskỳ

    Hormone Research
    |January 1, 1981
    PubMed
    Summary
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    Thyrotropin (TSH) is present in human breast milk at low concentrations. This study measured TSH levels in breast milk using radioimmunoassay, finding levels comparable to euthyroid adults.

    Area of Science:

    • Endocrinology
    • Lactation Biology
    • Reproductive Health

    Background:

    • Thyrotropin (TSH) is a crucial hormone regulating thyroid function.
    • The presence and concentration of TSH in human breast milk are not well-established.
    • Understanding TSH in breast milk may offer insights into infant endocrine development.

    Purpose of the Study:

    • To quantify the thyrotropin (TSH) content in human breast milk.
    • To compare TSH levels in breast milk with those found in euthyroid adults' serum.

    Main Methods:

    • Radioimmunoassay (RIA) was employed for TSH measurement.
    • A purification step using concanavalin A-Sepharose 4B chromatography was utilized.
    • 125I-TSH radioimmunoassay was performed on 15 human milk samples (1-13 weeks post-partum).

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    Main Results:

    • Human breast milk samples contained an average of 2.0 +/- 0.9 microU TSH/ml after purification.
    • Recovery rates of 125I-hTSH tracer were comparable in serum and milk standards.
    • Post-extraction TSH levels were not significantly different from direct assay results.

    Conclusions:

    • TSH is present in human breast milk at low concentrations.
    • These concentrations are comparable to those typically found in the serum of euthyroid adults.
    • Further research may explore the physiological significance of TSH in breast milk.