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Encephalitogenicity of measles virus in marmosets

P Albrecht, D Lorenz, M J Klutch

    Infection and Immunity
    |November 1, 1981
    PubMed

    Insights

    Marmosets infected with wild measles virus developed encephalitis, showing its neurotropic potential. This study highlights marmosets as key indicators for measles virus properties.

    Area of Science:

    • Virology
    • Neuroscience
    • Primatology

    Background:

    • Measles virus (MeV) is a significant human pathogen.
    • Understanding the neurotropic and viscerotropic potential of MeV strains is crucial for disease control.
    • Non-human primate models are essential for studying MeV pathogenesis.

    Purpose of the Study:

    • To evaluate marmosets as a model for studying the neurotropic and viscerotropic effects of measles virus.
    • To assess the pathogenicity of different measles virus strains in marmosets.

    Main Methods:

    • Intracerebral inoculation of marmosets with wild Edmonston and JM strains of measles virus.
    • Intracerebral inoculation of marmosets with a measles vaccine.
    • Histological examination and fluorescent-antibody technique to detect viral presence and encephalitis.
    • Clinical observation over a 14-day period.

    Main Results:

    • Intracerebral inoculation with the wild Edmonston strain induced encephalitis in marmosets, confirmed histologically and by immunofluorescence.
    • The Edmonston strain infection remained clinically silent during the observation period.
    • Intracerebral inoculation with the JM strain caused mild encephalitis but led to death from visceral measles.
    • Marmosets inoculated with measles vaccine showed no encephalitis and remained clinically healthy.

    Conclusions:

    • Marmosets are susceptible to measles virus infection, developing encephalitis with wild strains.
    • The study demonstrates the viscerotropic and neurotropic properties of measles virus in marmosets.
    • Marmosets serve as a sensitive indicator model for evaluating measles virus tropism and pathogenicity.

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