Polarographic analytical study of oxyphenbutazone

The polarographic behaviour of the widely used anti-inflammatory agent, oxyphenbutazone, was studied. It is determined polarographically by conversion to the nitroso derivative characterized by a cathodic, irreversible, diffusion-controlled wave. The method is applied to the determination of 2.5-10 mg/100 mL of oxyphenbutazone, with an accuracy of 99.9 +/- 1.38%. By differential pulse polarographic analysis, as little as 10 ppm oxyphenbutazone can be determined with an accuracy of 99.70 +/- 0.99% in pure powder and in some pharmaceutical formulations.