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Stimulus-sensitive spinal myoclonus

S M Davis, N M Murray, J V Diengdoh

    Journal of Neurology, Neurosurgery, and Psychiatry
    |October 1, 1981
    PubMed
    Summary
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    Spinal myoclonus, involuntary muscle jerks, can stem from viral neuronitis or spinal cord ischemia. Abnormal alpha motor neuron activity, potentially due to loss of internuncial neuron control, is implicated in these cases.

    Area of Science:

    • Neurology
    • Neuroscience
    • Spinal Cord Medicine

    Background:

    • Spinal myoclonus is a rare neurological disorder characterized by involuntary muscle contractions originating in the spinal cord.
    • Understanding the underlying pathophysiology is crucial for effective diagnosis and treatment.

    Observation:

    • Two cases of stimulus-sensitive spinal myoclonus, absent during sleep, are presented.
    • Case 1: Viral neuronitis with spontaneous resolution.
    • Case 2: Spinal cord ischemia with electrophysiological evidence of abnormal alpha motor neuron activity.

    Findings:

    • Histological examination in Case 2 revealed a significant reduction in small and intermediate neurons within the spinal cord.
    • Electrophysiological studies indicated aberrant activity in alpha motor neurons.

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    Implications:

    • These findings support the hypothesis that spinal myoclonus may arise from dysregulation of alpha motor neurons.
    • Loss of inhibitory control from spinal internuncial neurons could lead to abnormal motor neuron excitability.
    • Further research into spinal cord circuitry is warranted to elucidate mechanisms of myoclonus.