Experimental allergic encephalomyelitis (EAE) in two inbred guinea pigs. II. Strain differences in susceptibility to...

Two inbred strains of guinea pigs, Strain 13 and JY-1, were compared with regard to their susceptibility to the elicitation of experimental allergic encephalomyelitis (EAE) by passively transferred sensitized lymph node cells. Recipient guinea pigs were injected with more than 2 X 10(8) of viable lymph node cells from donors that had been immunized for the elicitation of EAE 8 days prior to the cell transfer. 1) Clinical course of EAE in all adult guinea pigs passively transferred with adult and juvenile sensitized lymph node cells was acute. 2) Sensitized cells required for successful passive transfer of EAE was less in JY-1 guinea pigs than in Strain 13 guinea pigs. 3) The sensitized cells from juvenile Strain 13 guinea pigs were less competent to transfer EAE than the adult ones whereas in JY-1 guinea pigs the juvenile cells were as effective as the adult ones.