[Hyperparathyroidism in hemodialysis patients: studies on parathyroid regulation and classification problems...

In a series of 22 patients undergoing chronic intermittent hemodialysis the response in secretion of parathyroid hormone (PTH) to an acute increase in serum calcium (Ca) concentration was studied. All patients had raised levels of predialysis PTH. Ca concentrations were measured by means of atomic absorption spectrophotometry and PTH concentrations were determined by radioimmunoassay. A close, significant, linear, negative correlation was demonstrated by regression analysis when Ca concentrations were correlated to changes in PTH, expressed as a percentage of the initial predialysis PTH value (100%). This finding supports the assumption that the function of the parathyroid gland at cellular level is similar in all patients, irrespective of very different predialysis PTH concentrations in peripheral blood. The results together with findings in literature were used to describe secondary hyperparathyroidism as a disease which shows typical phases during progression. Some still obscure phenomena of secondary hyperparathyroidism can be explained by discriminating between parathyroid function at a cellular and an organ level. The classification of hyperparathyroidism in regulative and autonomous forms only seems to be applicable when referred to the cellular level.