[Immunoglobulins A, M, and G in the cerebrospinal fluid of patients with ischemic stroke]

In 70 cases of ischaemic brain strokes and 25 cases serving as a reference group the levels of immunoglobulin A, M, G were determined in the cerebrospinal fluid. The obtained results demonstrated that in the studied group the mean levels of IgA and IgM and total protein were increased in the cerebrospinal fluid. The value of IgG was unchanged in relation to the control group. The rise in the mean levels of IgA and IgM was not always parallel with the rise in the total protein level. The authors discuss the importance of blood-brain barrier. Its role seems plausible in cases with raised levels of immunoglobulins and total protein. These changes in the levels of immunoglobulins can be a result of various concomitant local and systemic factors.