[Myeloma and hypereosinophilic leukemoid reaction (author's transl)]

In a 56-year-old man with a myeloma marked eosinophilia was discovered. The diagnosis of myeloma was made on the discovery of plasmocyte infiltration in the mandible. Despite surgery and chemotherapy, general bone infiltration by plasma cells occurred over 15 months. The leukocyte count rose to 226,000/mm3 with 162,720 mature eosinophils. Pathogenic problems suggested by such an unusual association (myeloma-eosinophilic leukemoid reaction) are considered.