Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental (-) emetine myopathy. Ultrastructural and morphometric observations

L Bindoff, M J Cullen

    Journal of the Neurological Sciences
    |November 1, 1978
    PubMed
    Summary

    (-) Emetine hydrochloride induces progressive skeletal muscle damage in rats, affecting myofibrils and mitochondria. Extensive membrane proliferation is a key feature, potentially forming autophagic vacuoles.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Myxoedema coma.

    Irish journal of medical science·2016
    Same author

    Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5.

    Oncogene·2010
    Same author

    Hypoglycaemia in an adult male: a surprising finding in pursuit of insulinoma.

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2008
    Same author

    Two cases of hypothalamic-pituitary sarcoidosis.

    Journal of the Royal Society of Medicine·2005
    Same author

    Neurocysticercosis: a rare cause of seizure.

    Irish medical journal·2004
    Same author

    The cost of managing diabetic foot ulceration in an Irish hospital.

    Irish journal of medical science·2004

    Area of Science:

    • Muscle biology
    • Toxicology
    • Cellular pathology

    Background:

    • (-) Emetine hydrochloride is a known myotoxic agent.
    • Understanding its effects on skeletal muscle is crucial for toxicology and neuromuscular disease research.

    Purpose of the Study:

    • To investigate the ultrastructural changes in rat skeletal muscle induced by (-) emetine hydrochloride.
    • To characterize the myopathy at a cellular level and identify key pathological features.

    Main Methods:

    • Administration of (-) emetine hydrochloride (2 mg/kg) to rats for one to four weeks.
    • Ultrastructural analysis of skeletal muscle tissue using electron microscopy.
    • Morphometric analysis to quantify cellular changes.

    Main Results:

    Related Experiment Videos

    • Progressive myopathy observed, affecting myofibrils (Z line streaming, rod formation, myofilament loss) and mitochondria (degeneration).
    • Extensive membrane proliferation was a prominent finding, implicated in autophagic vacuole formation.
    • Quantifiable changes in muscle fiber components were detected.

    Conclusions:

    • (-) Emetine hydrochloride induces a dose- and time-dependent myopathy in rat skeletal muscle.
    • Membrane proliferation and autophagic vacuole formation are significant pathological responses.
    • Ultrastructural and morphometric analyses provide detailed insights into drug-induced muscle injury.