Dissolution of azathioprine from tablets in forced laminar flow of liquid

The dissolution of azathioprine from tablets was investigated in a column apparatus with forced laminar liquid flow. The experiments showed that auxiliary ingredients and hydrodynamic factors affected the diffusion coefficient and solubility of the active principle and the density and viscosity of eluates from dissolution cell. For laminar flows changes in these physico-chemical parameters are described by a dimensionless equation (Formula: see text), where Sh--Sherwood number, Sc--Schmidt number, Re--Reynolds number, (Formula: see text)--grain dispersion in disintegrated tablet mass.