Short-term memory: the role of d-amphetamine

d-Amphetamine injections produce a dose-dependent disruption of performance within a discrete delayed alternation and a spatial delayed matching-to-sample task. Since d-amphetamine in the doses used had no deleterious effects on discrimination performance (no delay condition), it is suggested that d-amphetamine disrupts neuronal activity representing short-term memory. The data provide support for an independence model of short- and long-term memory.