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Phentolamine therapy in severe chronic asthmatiform bronchitis
Respiration; International Review of Thoracic Diseases
|January 1, 1981
Summary
Continuous phentolamine treatment improved well-being and blood gases in severe chronic bronchial obstruction patients. Corticosteroid therapy was reduced during oral phentolamine treatment.
Area of Science:
- Pulmonary Medicine
- Pharmacology
Background:
- Severe chronic bronchial obstruction presents significant challenges.
- Current treatments may have limitations or side effects.
Purpose of the Study:
- To evaluate the efficacy of phentolamine in severe chronic bronchial obstruction.
- To assess the impact on patient well-being, blood gases, and medication needs.
Main Methods:
- Continuous intravenous phentolamine infusion for 3 days in 6 patients.
- Subsequent 4-week oral phentolamine treatment (100 mg three times daily).
- Monitoring of subjective well-being, arterial blood gas values, ventilatory function, and pulmonary arterial pressure.
Main Results:
- Marked improvement in subjective well-being and arterial blood gas values.
- Ventilatory function and pulmonary arterial pressure remained largely unchanged.
- Significant reduction in chronic oral corticosteroid therapy was achieved.
Conclusions:
- Phentolamine shows promise in improving symptoms and gas exchange in severe chronic bronchial obstruction.
- It may allow for a reduction in corticosteroid use.
- Further research is warranted to confirm these findings.