Effect of digoxin upon intracellular potassium in man

The effect of digoxin upon intramuscular potassium was studied by use of whole body counting and biopsy technique. Twelve healthy subjects and twelve outpatients with mild cardiac insufficiency or atrial arrhythmia were digitalised. Before and after digitalization total body potassium (TBK) was measured. Potassium concentration in muscle specimens (MK) was analysed by the neutron activation technique. Digoxin was measured in serum and in skeletal muscle tissue by radioimmunoassay, and QS2-index as a measure of the electromechanical systole. In both groups a significant decrease in TBK (P less than 0.05) and MK (P less than 0.01) was demonstrated in connection to digitalization. There was no correlation between the decrease in TBK and MK, or between the concentrations of digoxin in serum or muscle and the decrease in potassium concentration. The digoxin in serum in healthy subjects was 0.9 +/- 0.33 nmol/l and in patients 1.2 +/- 0.41 nmol/l. The digoxin in muscle was 39 +/- 10.9 nmol/kg dry weight in seven of the healthy individuals and 37 +/- 9.5 nmol/kg dry weight in nine patients. After digitalization a decrease of QS2-index was found in both groups (P less than 0.01).