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Surgery in patients with hemoglobin-S disease
Journal of Pediatric Surgery
|December 1, 1978
Summary
Surgery in sickle cell disease patients, particularly those with hemoglobin-S, requires careful management. Associated conditions significantly influence surgical procedures and complications, with infections being most common.
Area of Science:
- Hematology
- Surgical Medicine
Background:
- Sickle cell disease (SCD) is a genetic blood disorder with significant implications for surgical patients.
- Patients with SCD often have co-existing conditions that complicate surgical management.
Purpose of the Study:
- To review surgical outcomes in patients with sickle cell disease.
- To identify common procedures and complications in this patient population.
Main Methods:
- Retrospective review of 68 patients with sickle cell disease who underwent surgery.
- Analysis of patient demographics, associated diseases, surgical procedures, and complications.
Main Results:
- 52 patients were homozygous for hemoglobin-S; 16 had heterozygous variants.
- Common major operations included splenectomy (12) and cholecystectomy (11).
- Infections were the most frequent complication, occurring in 21 patients.
Conclusions:
- Associated diseases heavily influence surgical procedures and complications in SCD patients.
- Precise management strategies led to acceptably low morbidity and mortality (1 death).