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Methyl chloride and diazepam effects on performance

V Putz-Anderson, J V Setzer, J S Croxton

    Scandinavian Journal of Work, Environment & Health
    |March 1, 1981
    PubMed
    Summary
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    Diazepam significantly impaired cognitive tasks by 10%, while methyl chloride (MeCl) showed a minor effect. Combined exposure resulted in additive behavioral impairments, highlighting individual differences in MeCl levels.

    Area of Science:

    • Neuroscience
    • Occupational Health
    • Psychopharmacology

    Background:

    • Diazepam is a common anxiolytic with known central nervous system effects.
    • Methyl chloride (MeCl) is an industrial chemical with potential neurotoxic properties.
    • Understanding combined exposure effects is crucial for workplace safety and clinical practice.

    Purpose of the Study:

    • To investigate the human behavioral effects of diazepam and methyl chloride (MeCl) exposure.
    • To assess the impact of combined diazepam and MeCl on cognitive and psychomotor performance.
    • To determine the dose-dependent effects of MeCl on human behavior.

    Main Methods:

    • Fifty-six volunteers were randomly assigned to groups receiving diazepam, placebo, MeCl (100 or 200 ppm), or combinations.

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  • Participants completed tasks measuring eye-hand coordination, mental alertness, and time discrimination in a controlled environment.
  • Pretreatment and post-exposure data were collected to quantify performance changes.

    • Main Results:

    • Diazepam ingestion caused a significant 10% average impairment in task performance.
    • Inhalation of 200 ppm MeCl resulted in a marginally significant 4.5% average performance impairment.
    • Combined exposure to diazepam and MeCl led to additive impairments, with significant interindividual variability in MeCl blood and breath levels.

    Conclusions:

    • Diazepam exerts a notable detrimental effect on human behavioral performance.
    • Methyl chloride exposure, even at 200 ppm, has a less pronounced but significant impact.
    • The combined effects of diazepam and MeCl are additive, underscoring the importance of considering multiple exposures in occupational and clinical settings.