[Organic hemodynamics in modelled acute pancreatitis]

Area of Science:

• Vascular Surgery
• Gastroenterology
• Biomedical Engineering

Background:

• Acute pancreatitis significantly impacts pancreatic hemodynamics, leading to organ dysfunction.
• Assessing blood pressure in pancreatic vessels is crucial for understanding disease progression and treatment efficacy.
• Existing methods for evaluating pancreatic hemodynamics during pancreatitis require enhancement.

Purpose of the Study:

• To evaluate pancreatic blood pressure monitoring as a method for assessing hemodynamic disturbances in acute pancreatitis.
• To investigate the effectiveness of curative measures, specifically permanent magnetic field therapy, in managing acute pancreatitis-induced hemodynamic changes.

Main Methods:

• Surgical procedures involving the pancreas and its vessels.
• In vivo measurement of blood pressure within pancreatic vessels.
• Modeling of acute pancreatitis in a relevant biological system.
• Application of permanent magnetic field therapy.

Main Results:

• Acute pancreatitis was associated with decreased arterial pressure, altered blood flow patterns (impulse to continuous), loss of pulse pressure, and zero blood pressure.
• Observed complications included vascular thrombosis and hemorrhages in the pancreas.
• Permanent magnetic field therapy demonstrated effectiveness in reversing organo-hemodynamic disorders during the reversible stage of acute pancreatitis.

Conclusions:

• Pancreatic blood pressure measurement is a valuable tool for assessing hemodynamic integrity in acute pancreatitis.
• Magnetic field therapy offers a potential therapeutic strategy for managing reversible hemodynamic disturbances in acute pancreatitis.