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[Dynamics of succinate dehydrogenase activity to premature infants with hypothalamic brain damage]
Insights
Early cytochemical tests measuring lymphocyte succinate dehydrogenase (SDH) activity in premature infants can predict future delays in psychic development and neurological syndromes. This aids in early intervention for high-risk newborns.
Area of Science:
- Biochemistry
- Developmental Pediatrics
- Neonatology
Context:
- Premature infants are at higher risk for neurodevelopmental issues.
- Early identification of neurodevelopmental delays is crucial for timely intervention.
- Cytochemical markers offer potential for predictive diagnostics in neonates.
Purpose:
- To investigate the correlation between specific cytochemical markers in prematurely born infants and their subsequent neuropsychic development.
- To assess the predictive value of lymphocyte succinate dehydrogenase (SDH) and neutrophil alkaline phosphatase (AP) activity for neurodevelopmental outcomes.
- To establish the utility of these cytochemical examinations for forecasting and managing neurodevelopmental trajectories in high-risk infants.
Summary:
- This study examined lymphocyte succinate dehydrogenase (SDH) and neutrophil alkaline phosphatase (AP) activity in 70 premature infants.
- Long-term follow-up (up to 6-7 years) assessed neuropsychic development.
- High SDH activity levels were found to be highly informative in predicting delayed psychic development and neurological syndromes in these children.
Impact:
- The findings support the use of SDH activity testing in infants with perinatal hypoxic brain damage.
- Cytochemical examinations can aid in forecasting neuropsychic development and guiding early, individualized therapeutic strategies.
- This research highlights a potential non-invasive method for early risk stratification and personalized care in premature infants.
Abstract:
Cytochemical examinations of the activity of lymphocyte succinate dehydrogenase (SDH) and neutrophil alkaline phosphatase (AP) were carried out in 70 prematurely born infants. Later catamnestic observations of the neuropsychic development of these children were carried out up to the age of 6 to 7 years. An analysis of correlations between the cytochemical findings and the data on the neuropsychic status showed a high informative value of the SDH activity level for forecasting subsequent delay of the psychic development, as well as some other neurological syndromes in prematurely born children. The data obtained give one grounds of recommend cytochemical examinations of infants with perinatal hypoxic damage of the brain for forecasting their subsequent neuropsychic development and instituting early correcting and individual therapy.