Related Experiment Video
Updated: Aug 7, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Genetic independence of manic-depression and schizophrenia
Abstract:
Increasingly sophisticated twin and adoption research has demonstrated major genetic contributions to the etiology of manic-depression and schizophrenia. But studies disagree concerning whether the two are genetically related illnesses. This lack of consensus could be due to individual, regional, and temporal differences in the criteria used to diagnose the two conditions. This study is the first to employ the new DSM-III criteria. Schizophrenia was no more common in the 1,098 first-degree relatives of 100 male and 100 female manic-depressives than it is in the population at-large. This would appear to strengthen the view that manic-depression and schizophrenia are genetically unrelated diseases.
Related Concept Videos
Law of Independent Assortment
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Bipolar Disorder
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia

